Anti-HEXIM1 monoclonal antibody (DMABT-H13907)

Mouse anti-Human HEXIM1 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
5H5
Species Reactivity
Human
Immunogen
HEXIM1 (AAH06460,2a.a. ~ 359 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
HEXIM1; hexamethylene bis-acetamide inducible 1; protein HEXIM1; CLP 1; EDG1; HIS1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM2. Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
Antigen Description
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene. 0The function about HEXIM1 antigen include cyclin-dependent protein kinase inhibitor activity; protein binding; snRNA binding.

Citations


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References


Krueger, BJ; Varzavand, K; et al. The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK. PLOS ONE 5:-(2010).
Fujimoto, Y; Nakamura, Y; et al. HEXIM1-binding elements on mRNAs identified through transcriptomic SELEX and computational screening. BIOCHIMIE 94:1900-1909(2012).

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