Tag/Conjugate
Unconjugated
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Function
protein binding;
Synonyms
GEMIN7; gem (nuclear organelle) associated protein 7; SIP3; gem-associated protein 7; gemin 7; gemin-7;
Citations
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Todd, AG; Morse, R; et al. Analysis of SMN-neurite granules: Core Cajal body components are absent from SMN-cytoplasmic complexes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 397:479-485(2010).
Carissimi, C; Saieva, L; et al. Gemin8 is required for the architecture and function of the survival motor neuron complex. JOURNAL OF BIOLOGICAL CHEMISTRY 281:37009-37016(2006).