Human GPX4 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-GPX4 (Isoform a and c) antibody

Target

GPX4 (Isoform a and c)

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants.

Function

glutathione peroxidase activity; oxidoreductase activity; phospholipid-hydroperoxide glutathione peroxidase activity;

Synonyms

GPX4; glutathione peroxidase 4; glutathione peroxidase 4 (phospholipid hydroperoxidase); phospholipid hydroperoxide glutathione peroxidase, mitochondrial; MCSP; PHGPx; phospholipid hydroperoxidase; sperm nucleus glutathione peroxidase; GPx-4; snGPx; GSHPx-4; snPHGPx;