Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide, corresponding to residues in Mouse Glutathione Peroxidase 4.
Applications
Application Notes
WB: 1/1000 - 1/10000; IP: 1/10 - 1/100; IHC-P: 1/100 - 1/250; ICC: 1/50 - 1/100;
Target
Alternative Names
GPX4; glutathione peroxidase 4; phospholipid hydroperoxide glutathione peroxidase, nuclear; GPx-4; GSHPx-4; sperm nuclei glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; PHGPx; snGPx; mtPHGPx; 1700027O09Rik; MGC103
Product Background
Antigen Description
Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.
Pathway
Folic Acid Network, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; One carbon metabolism and related pathways, organism-specific biosystem; Selenium metabolism/Selenoproteins, organism-specific biosystem; glutathione redox reactions I, organism-specific biosystem;
Citations
Publication ()
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