This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Function
DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; chromatin binding; metal ion binding; microtubule binding; protein binding; transcription regulatory region DNA binding;
Synonyms
GLI1; GLI family zinc finger 1; GLI; zinc finger protein GLI1; oncogene GLI; glioma-associated oncogene 1; GLI-Kruppel family member GLI1; glioma-associated oncogene homolog 1 (zinc finger protein);
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