Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
Pathway
Basal cell carcinoma; Hedgehog Signaling Pathway; Hedgehog signaling events mediated by Gli proteins; Hedgehog signaling pathway; Pathways in cancer;
Citations
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