Product Overview
Blocking/Immunizing peptide for anti-FRAT1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.
Synonyms
FRAT1; frequently rearranged in advanced T-cell lymphomas; proto-oncogene FRAT1; FRAT-1; frequently rearranged in advanced T-cell lymphomas 1; FLJ97193;
Citations
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Wang, Y; Hewitt, SM; et al. Tissue microarray analysis of human FRATI expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. BRITISH JOURNAL OF CANCER 94:686-691(2006).
Li, BL; Ryder, J; et al. FRAT1 peptide decreases A beta production in swAPP(751) cells. FEBS LETTERS 553:347-350(2003).
COA
Certificate of Analysis
