The protein encoded by the FRAT1 gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and also positively regulates the Wnt signaling pathway. It may play a role in tumor progression and in lymphomagenesis.
Pathway
Beta-catenin phosphorylation cascade; DNA damage response (only ATM dependent); Degradation of beta-catenin by the destruction complex; Presenilin action in Notch and Wnt signaling; Signal Transduction; Signaling by Wnt; Wnt Signaling Pathway
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