The protein encoded by the FRAT1 gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and also positively regulates the Wnt signaling pathway. It may play a role in tumor progression and in lymphomagenesis.
Pathway
Beta-catenin phosphorylation cascade; DNA damage response (only ATM dependent); Degradation of beta-catenin by the destruction complex; Presenilin action in Notch and Wnt signaling; Signal Transduction; Signaling by Wnt; Wnt Signaling Pathway
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Li, BL; Ryder, J; et al. FRAT1 peptide decreases A beta production in swAPP(751) cells. FEBS LETTERS 553:347-350(2003).
Wang, Y; Hewitt, SM; et al. Tissue microarray analysis of human FRATI expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. BRITISH JOURNAL OF CANCER 94:686-691(2006).
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COA
Certificate of Analysis
