Product Overview
Blocking/Immunizing peptide for anti-FOXC2 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues.
Function
DNA binding, bending; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; chromatin DNA binding; double-stranded DNA binding; sequence-specific DNA b
Synonyms
FOXC2; forkhead box C2 (MFH-1, mesenchyme forkhead 1); FKHL14; forkhead box protein C2; MFH 1; MFH-1,mesenchyme forkhead 1; transcription factor FKH-14; mesenchyme fork head protein 1; forkhead-related protein FKHL14; forkhead, Drosophila, homolog-like 14; LD; MFH1; MFH-1;
Citations
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Katoh, M; Katoh, M; et al. Integrative genomic analyses of CXCR4: Transcriptional regulation of CXCR4 based on TGF beta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors. INTERNATIONAL JOURNAL OF ONCOLOGY 36:415-420(2010).
Gronning, LM; Cederberg, A; et al. Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways. MOLECULAR ENDOCRINOLOGY 16:873-883(2002).