Synthetic Human CASP8AP2 blocking peptide for BL, WB
Cytoplasm. Nucleus. Localizes to discrete nuclear foci.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. PBS with 0.1% BSA 0.02% sodium azide pH7.2
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
DNA binding; SUMO polymer binding; cysteine-type endopeptidase activator activity involved in apoptotic process; death receptor binding; peptidase activator activity involved in apoptotic process; protein binding; transcription corepressor activity;
CASP8AP2; caspase 8 associated protein 2; CED-4; FLASH; RIP25; CASP8-associated protein 2; human FLASH; FLASH homolog RIP25; FLICE associated huge; CASP8 associated protein 2; FLICE-associated huge protein;