Anti-CASP8AP2 polyclonal antibody (DPABH-03985)

Rabbit anti-Human CASP8AP2 polyclonal antibody for IHC-P, WB, ICC/IF Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to Human FLASH aa 1950 to the C-terminus conjugated to Keyhole Limpet Haemocyanin (KLH).Database link: Q9UKL3
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 0.1 μg/ml; WB: 1 μg/ml; ICC/IF: 1 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CASP8AP2; caspase 8 associated protein 2; CED-4; FLASH; RIP25; CASP8-associated protein 2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CASP8AP2 (Caspase 8 Associated Protein 2) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and Apoptosis and survival Caspase cascade. GO annotations related to this gene include identical protein binding and protease binding. This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
Antigen Description
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. CASP8-associated protein 2 is a protein that in humans is encoded by the CASP8AP2 gene. This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. The function about CASP8AP2 antigen include DNA binding; SUMO polymer binding; cysteine-type endopeptidase activator activity involved in apoptotic process; death receptor binding.
Pathway
TNF-alpha/NF-kB Signaling Pathway.

Citations


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References


Oliveira, RDR; Fontana, V; et al. Differential Gene Expression Profiles May Differentiate Responder and Nonresponder Patients with Rheumatoid Arthritis for Methotrexate (MTX) Monotherapy and MTX plus Tumor Necrosis Factor Inhibitor Combined Therapy. JOURNAL OF RHEUMATOLOGY 39:1524-1532(2012).
Chen, S; Evans, HG; et al. FLASH Knockdown Sensitizes Cells To Fas-Mediated Apoptosis via Down-Regulation of the Anti-Apoptotic Proteins, MCL-1 and Cflip Short. PLOS ONE 7:-(2012).

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