This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
Function
5-3 exodeoxyribonuclease activity; 5-3 exonuclease activity; DNA binding; double-stranded DNA specific 5-3 exodeoxyribonuclease activity; endonuclease activity; exonuclease activity; exonuclease activity; flap endonuclease activity; metal ion binding; pro
Synonyms
EXO1; exonuclease 1; HEX1; hExoI; rad2 nuclease family member; homolog of S. cerevisiae exonuclease 1; hExo1; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1;
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