Human ESX1 blocking peptide (CDBP1158)

Synthetic Human ESX1 blocking peptide for BL

Product Overview
Blocking peptide for anti-ESX1 antibody
Target
ESX1
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.
Function
sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
Synonyms
ESX1; ESX homeobox 1; ESX1L, extraembryonic, spermatogenesis, homeobox 1 homolog (mouse); homeobox protein ESX1; ESXR1; ESX1-related protein; extraembryonic, spermatogenesis, homeobox 1 homolog; ESX1L;

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References


Nishiyama, A; Xin, L; et al. Uncovering Early Response of Gene Regulatory Networks in ESCs by Systematic Induction of Transcription Factors. CELL STEM CELL 5:420-433(2009).
Yan, YT; Stein, SM; et al. A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein. MOLECULAR AND CELLULAR BIOLOGY 20:661-671(2000).

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