Anti-ESX1 (aa 124-213) polyclonal antibody

Species Reactivity

Human

Immunogen

ESX1L (NP_703149, 124 a.a. ~ 213 a.a) partial recombinant protein with GST tag. The sequence is AEGPQTAEGPQPPERKRRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRV QVWFQNRRAKWKRNQRVLMLRNTATADLAH

Conjugate

Alternative Names

ESX1; ESX homeobox 1; ESX1L; ESXR1; homeobox protein ESX1; ESX1-related protein; extraembryonic, spermatogenesis, homeobox 1 homolog;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.