This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants.
Function
SH3 domain binding; protein binding;
Synonyms
ELMO1; engulfment and cell motility 1; engulfment and cell motility 1 (ced 12 homolog, C. elegans); engulfment and cell motility protein 1; CED 12; CED12; ELMO 1; KIAA0281; ced-12 homolog 1; CED-12; ELMO-1; MGC126406;
Citations
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