HCV E1 protein (DAG3203)

HCV E1 protein, recombinant protein from E. coli Datasheet

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Product Overview
Recombinant Hepatitis C virus E1
Nature
Recombinant
Tag/Conjugate
Unconjugated
Purity
95% by SDS-PAGE
Buffer
25 mM Tris-HCl, 0.1% SDS, pH 8.3
Storage
2-8°C short term, -20°C long term
Introduction
Envelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells.
Antigen Description
Envelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral l
Keywords
E1 envelope glycoprotein; HCV envelope glycoprotein; Hepatitis C Virus envelope glycoprotein; HCV E1

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