Product Overview
Blocking/Immunizing peptide for anti-Desmin antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
Function
cytoskeletal protein binding; identical protein binding; protein binding; structural constituent of cytoskeleton;
Synonyms
DES; desmin; CSM1; CSM2; LGMD2R; mutant desmin p.K241E; intermediate filament protein;
Citations
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Tatic, V; Rafajlovski, S; et al. Histochemical and immunohistochemical analyses of the myocardial scar fallowing acute myocardial infarction. VOJNOSANITETSKI PREGLED 69:581-588(2012).
Sanbe, A; Marunouchi, T; et al. Phenotype of Cardiomyopathy in Cardiac-specific Heat Shock Protein B8 K141N Transgenic Mouse. JOURNAL OF BIOLOGICAL CHEMISTRY 288:8910-8921(2013).