General Notes
This product (Catalog No. DPABH-00119) is a rabbit-derived polyclonal antibody raised against human Desmin, targeting the amino acid region 1–470 of the protein. This antibody exhibits cross-reactivity with Human Desmin from mouse and rat. It has been affinity purified by Protein A. Desmin is a muscle-specific type III intermediate filament protein encoded by the DES gene located on the long arm of chromosome 2 (2q35) in humans, consisting of 470 amino acids with a molecular weight of approximately 53 kDa. It forms a crucial cytoskeletal scaffold in skeletal, cardiac, and smooth muscle cells, surrounding Z-discs in striated muscles and dense bodies in smooth muscles to link myofibrils to the plasma membrane, nucleus, mitochondria, and other organelles, thereby ensuring mechanical stability, force transmission during contraction, and overall muscle integrity. Expressed early in myogenesis and highly abundant in differentiated muscle tissues—such as 2% of total protein in cardiac muscle and 0.35% in skeletal muscle—desmin is regulated by multiple transcription factors and plays a key role in sarcomere organization, mitochondrial function, and proteostasis.
DPABH-00119 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-00119 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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