Daxx ( C - term ) peptide ( human )

Daxx

Synthetic

Human

Unconjugated

0.2 mg/ml

50 μg

PBS with 0.1% BSA 0.02% sodium azide pH7.2

Upon receipt - Keep as concentrated solution. Aliquot and store at -20^oC or below. Avoid freeze-thaw cycles.

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

androgen receptor binding; enzyme binding; heat shock protein binding; p53 binding; protein N-terminus binding; protein binding; protein homodimerization activity; receptor signaling protein activity; transcription coactivator activity; transcription fact

DAXX; death-domain associated protein; death associated protein 6; death domain-associated protein 6; DAP6; Fas-binding protein; CENP-C binding protein; ETS1-associated protein 1; death-associated protein 6; fas death domain-associated protein; EAP1; BING2; MGC126245; MGC126246;