Anti-DAXX (aa 561-660) polyclonal antibody

Species Reactivity

Human

Immunogen

DAXX (NP_001341, 561 a.a. ~ 660 a.a) partial recombinant protein with GST tag. The sequence is SPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPH NWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNG

Conjugate

Alternative Names

DAXX; death-domain associated protein; DAP6; EAP1; BING2; death domain-associated protein 6; Fas-binding protein; CENP-C binding protein; ETS1-associated protein 1; death-associated protein 6; fas death domain-associated protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

Pathway

Amyotrophic lateral sclerosis (ALS); Apoptosis Modulation and Signaling; HIV-1 Nef: Negative effector of Fas and TNF-alpha; IL-6 Signaling Pathway