Specificity
Present in vascular smooth cells (at protein level).
Tag/Conjugate
Unconjugated
SequenceSimilarities
Belongs to the helicase family.Contains 2 CARD domains.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.
Alternative Names
The repressor domain controls homomultimerization and interaction with MAVS.The helicase domain is responsible for dsRNA recognition.The 2 CARD domains are responsible for interaction with and signaling through MAVS.The second CARD domain is the primary s
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008]
Function
ATP binding; ATP-dependent helicase activity; double-stranded DNA binding; double-stranded RNA binding; double-stranded RNA binding; double-stranded RNA binding; identical protein binding; protein binding; single-stranded RNA binding; zinc ion binding;
Synonyms
DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; RIGI; RIG-I; RLR-1; probable ATP-dependent RNA helicase DDX58; RIG-1; RNA helicase RIG-I; DEAD box protein 58; RIG-I-like receptor 1; retinoic acid inducible gene I; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide;
Citations
Publication ()
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COA
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