Anti-DDX58 (aa 200-250) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Monkey

Immunogen

Synthetic peptide corresponding to a region within amino acids 200-250 of Human DDX58 (NP_055129.2).

Conjugate

Application Notes

WB: 2 - 4 μg/ml; IHC-P: 5 - 10 μg/ml.

Alternative Names

DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; probable ATP-dependent RNA helicase DDX58; DKFZp434J1111; FLJ13599; retinoic acid inducible gene I; RIG I; RNA helicase RIG I; RIG-1; RNA helicase RIG-I; DEAD box protein 58; retinoic acid-inducible gene 1

Entrez Gene ID

UniProt ID

Antigen Description

Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). Essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.

Pathway

Antiviral mechanism by IFN-stimulated genes; Cytokine Signaling in Immune system; Cytosolic DNA-sensing pathway; Hepatitis C; Herpes simplex infection;