Rabbit Anti-Human DAZ4 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Fusion protein corresponding to a region derived from internal residues of human Deleted in azoospermia protein 4

Conjugate

Application Notes

IHC: 1:25-1:100

General Notes

This product (Catalog No. CABT-BL4474) is a rabbit-derived IgG polyclonal antibody raised against human DAZ4. It has been affinity purified by protein A. This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described.
CABT-BL4474 is suitable for use in IHC (1:25–1:100) application.
CABT-BL4474 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

pDP1680; pDP1681

Entrez Gene ID

UniProt ID