Anti-DAZ4 monoclonal antibody (DCABH-11218) Made to order

Rabbit anti-Human DAZ4 monoclonal antibody for WB, ELISA

View other DAZ4 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DAZ4 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DAZ4; deleted in azoospermia 4; deleted in azoospermia protein 4; pDP1680; pDP1681
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DAZ4 (Deleted In Azoospermia 4) is a Protein Coding gene. Diseases associated with DAZ4 include azoospermia and klinefelters syndrome. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DAZL. This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2. 4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10. 8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10. 8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described.
Antigen Description
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2. 4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10. 8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10. 8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=The disease may be caused by mutations affecting the gene represented in this entry. AZFc deletions in the Yq11. 23 region including the DAZ genes are the most common known genetic cause of human male infertility. The function about DAZ4 antigen include RNA binding; nucleotide binding.

Citations


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References


Dyce, PW; Shen, W; et al. Analysis of Oocyte-Like Cells Differentiated from Porcine Fetal Skin-Derived Stem Cells. STEM CELLS AND DEVELOPMENT 20:809-819(2011).
Jung, H; Song, H; et al. The KIT is a putative marker for differentiating spermatogonia in stallions. ANIMAL REPRODUCTION SCIENCE 152:39-46(2015).

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