Human DAB2 peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Function

AP-2 adaptor complex binding; SMAD binding; cargo receptor activity; clathrin adaptor activity; integrin binding; phosphatidylinositol-4,5-bisphosphate binding; protein C-terminus binding; protein binding;

Synonyms

DAB2; Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila); DOC2; DOC-2; disabled homolog 2; differentially-expressed protein 2; disabled homolog 2, mitogen-responsive phosphoprotein;