Specifications
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)
Applications
Application Notes
WB: 1/1000 - 1/5000; IP: 1/10; Flow Cyt: 1/50;
Target
Alternative Names
DAB2; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein); disabled homolog 2; DOC 2; differentially-expressed protein 2; DOC2; DOC-2; FLJ26626;
Product Background
Antigen Description
DAB2 is a component of the CSF1 signal transduction pathway. DAB2 mRNA is expressed in normal ovarian epithelial cells but is down regulated or absent from ovarian carcinoma cell lines. The down regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2 like domains, alpha and beta).
Pathway
Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Formation of annular gap junctions, organism-specific biosystem; Gap junction degradation, organism-specific biosystem; Gap junction trafficking, organism-specific biosystem; Gap junction trafficking and regulation, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem.
Citations
Publication ()
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COA
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