Human POR peptide

Name: Human POR peptide
SKU: DAG-P1494
Rating: 5 (1 reviews)

Regulatory status: For research use only, not for use in diagnostic procedures.

COA

SDS

Datasheet

Summary

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

POR peptide is a synthetic peptide corresponding to the internal region of CYPOR.

Purity

> 95 % by SDS-PAGE.

Format

Lyophilized

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Reconstitution

POR peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.

Introduction

This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]

Entrez Gene ID

5447

Synonyms

POR; P450 (cytochrome) oxidoreductase; CPR; CYPOR; P450R; NADPH--cytochrome P450 reductase; NADPH-dependent cytochrome P450 reductase;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Espana a traves de los ojos de un demonologo ingles: leyenda negra, brujeria y supersticion enThe Discoverie of Witchcraft(1584) de Reginald Scot

BULLETIN OF SPANISH STUDIES

Authors: Mendez, Agustin

Abstract

El presente articulo analiza el tratado demonologicoThe Discoverie of Witchcraftde Reginald Scot con la intencion de demostrar que el autor utilizo sus particulares ideas sobre la brujeria y su critica a las supersticiones para construir un discurso hispanofobico que respondio a las tensiones geopoliticas existentes entre las monarquias inglesa y espanola, por lo que el mencionado texto puede ser considerado como un capitulo mas en el desarrollo de la leyenda negra, algo hasta aqui no advertido por otros historiadores. A su vez, tambien se intentara comprobar que la retorica del espejo invertido utilizada por el demonologo para confeccionar el estereotipo de lo espanol podria corresponder con una fase embrionaria en el establecimiento de las bases ideologicas para la creacion de un imperio ingles.

Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

JOURNAL OF CLINICAL MEDICINE

Authors: Sfakianoudis, Konstantinos; Simopoulou, Mara; Grigoriadis, Sokratis; Pantou, Agni; Tsioulou, Petroula; Maziotis, Evangelos; Rapani, Anna; Giannelou, Polina; Nitsos, Nikolaos; Kokkali, Georgia; Koutsilieris, Michael; Pantos, Konstantinos

Abstract

Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot studies were conducted on poor ovarian response (POR), premature ovarian insufficiency (POI), perimenopause, and menopause, respectively. Each pilot study reports on thirty patients, 120 participants were recruited in total. All participants provided written informed consent prior to treatment. Primary outcome measures for the POR pilot study were levels of anti-mullerian hormone (AMH), antral follicle count (AFC) and oocyte yield. For the POI, perimenopausal and menopausal pilot studies primary outcome measures were restoration of menstrual cycle, and Follicle Stimulating Hormone (FSH) levels. A significant improvement on the hormonal profile and the ovarian reserve status was noted, along with improved intracytoplasmic sperm injection (ICSI) cycle performance concerning POR participants. Menstruation recovery was observed in 18 out of 30 POI patients, along with a statistically significant improvement on levels of AMH, FSH, and AFC. Similarly, 13 out of 30 menopausal women positively responded to PRP treatment. Finally, menstruation regularity, improved hormonal levels and AFC were reported for 24 out of 30 perimenopausal women. To conclude, PRP infusion appears to convey promising results in addressing ovarian insufficiency.