CTSK blocking peptide (DAG-P1358)

Synthetic CTSK blocking peptide for WB, BL Datasheet

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Specificity
Predominantly expressed in osteclasts (bones).
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the peptidase C1 family.
Cellular Localization
Lysosome.
Purity
> 95 % by SDS-PAGE.
Format
Liquid
Buffer
Preservative: 0.02% Thimerosal (merthiolate) Constituents: 0.1% BSA, PBS, pH 7.2
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. Preservative: 0.02% Thimerosal (merthiolate) Constituents: 0.1% BSA, PBS, pH 7.2
UniProt ID
Antigen Description
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Function
collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; proteoglycan binding;
Synonyms
CTSK; cathepsin K; CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2;

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