Anti-CLK3 monoclonal antibody (DMABT-H13451)

Mouse anti-Human CLK3 monoclonal antibody for WB, IHC, IF, ELISA, RNAi Knockdown Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
2G20
Species Reactivity
Human
Immunogen
CLK3 (AAH02555,47a.a. ~ 136 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CLK3; CDC-like kinase 3; dual specificity protein kinase CLK3; clk3; PHCLK3; PHCLK3/152
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLK3 (CDC Like Kinase 3) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is CLK4. This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9.
Antigen Description
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene. The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain. 0The function about CLK3 antigen include ATP binding; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity.
Pathway
mRNA processing, organism-specific biosystem.

Citations


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References


Starr, R; Hall, FL; et al. A cdc2-like kinase distinct from cdk5 is associated with neurofilaments. JOURNAL OF CELL SCIENCE 109:1565-1573(1996).

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