General Notes
This product (Catalog No. CABT-BL4375) is a rabbit-derived IgG polyclonal antibody raised against human CLDN12, targeting the amino acid region 32–87 of the protein. This antibody exhibits cross-reactivity with CLDN12 from mouse, rat, dog, pig, cow, and horse. It has been affinity purified by protein A. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.
CABT-BL4375 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
CABT-BL4375 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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