Rabbit Anti-Human CLCN4 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from internal of human CLCN4.

Conjugate

Application Notes

WB: 1:500-1:3000
IF: 1:100-1:500

General Notes

This product (Catalog No. CABT-BL4367) is a rabbit-derived IgG polyclonal antibody raised against human CLCN4. This antibody exhibits cross-reactivity with CLCN4 from mouse and rat. It has been affinity purified by protein A. The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.
CABT-BL4367 is suitable for use in Western blot (WB) (1:500–1:3,000), IF (immunofluorescence) (1:100–1:500) applications.
CABT-BL4367 is supplied as a liquid formulation in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

chloride channel 4; ClC-4; ClC-4A; CLC4; MGC163150

Entrez Gene ID

UniProt ID