Anti-CLCN4 monoclonal antibody (DCABH-11031) Made to order

Rabbit anti-Human CLCN4 monoclonal antibody for WB, ELISA

View other CLCN4 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CLCN4 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CLCN4; chloride channel, voltage-sensitive 4; chloride channel 4; H(+)/Cl(-) exchange transporter 4; ClC 4; CLC4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLCN4 (Chloride Voltage-Gated Channel 4) is a Protein Coding gene. Diseases associated with CLCN4 include ocular albinism and dent disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Hepatic ABC Transporters. GO annotations related to this gene include ion channel activity and antiporter activity. An important paralog of this gene is CLCN7. The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22. 3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.
Antigen Description
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22. 3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. H(+)/Cl(-) exchange transporter 4 is a protein that in humans is encoded by the CLCN4 gene. The function about CLCN4 antigen include ATP binding; antiporter activity; chloride channel activity; ion channel activity; nucleotide binding; voltage-gated chloride channel activity.

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References


Li, XH; Shimada, K; et al. Biophysical properties of ClC-3 differentiate it from swelling-activated chloride channels in Chinese hamster ovary-K1 cells. JOURNAL OF BIOLOGICAL CHEMISTRY 275:35994-35998(2000).
Senseman, DM; et al. High-speed optical imaging of afferent flow through rat olfactory bulb slices: Voltage-sensitive dye signals reveal periglomerular cell activity. JOURNAL OF NEUROSCIENCE 16:313-324(1996).

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