The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Function
LBD domain binding; RNA polymerase II activating transcription factor binding; RNA polymerase II transcription coactivator activity; RNA polymerase II transcription corepressor activity; SMAD binding; chromatin binding; histone acetyltransferase binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription corepressor activity
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