The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Function
2 iron, 2 sulfur cluster binding; metal ion binding; poly(A) RNA binding; protein binding; protein homodimerization activity
Synonyms
CISD2; CDGSH iron sulfur domain 2; ERIS; WFS2; ZCD2; NAF-1; Miner1; CDGSH iron-sulfur domain-containing protein 2; mitoNEET-related 1 protein; zinc finger, CDGSH-type domain 2; nutrient-deprivation autophagy factor-1; endoplasmic reticulum intermembrane small protein
Citations
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