Anti-CDK19 monoclonal antibody (DMABT-H13372)

Mouse anti-Human CDK19 monoclonal antibody for IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4E8
Species Reactivity
Human
Immunogen
CDC2L6 (NP_055891.1,2a.a. ~ 114 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CDK19; cyclin-dependent kinase 19; CDC2L6, CDK11, cell division cycle 2 like 6 (CDK8 like) , cyclin dependent kinase (CDC2 like) 11; bA346C16.3; KIAA1028; death-preventing kinase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CDK19 (Cyclin-Dependent Kinase 19) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK8. This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Antigen Description
Protein Symbol:Q9BWU1-CDK19_HUMANRecommended name:Cyclin-dependent kinase 19Protein Accession:Q9BWU1Secondary Accessions:Q5JQZ7Q5JR00Q8TC78Q9UPX2The function about CDK19 antigen include ATP binding; cyclin-dependent protein kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity, transferring phosphorus-containing groups.
Pathway
Developmental Biology, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem; Transcriptional Regulation of White Adipocyte Differentiation, org.

Citations


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References


Lidhar, K; Korbonits, M; et al. Low expression of the cell cycle inhibitor p27(Kip1) in normal corticotroph cells, corticotroph tumors, and malignant pituitary tumors. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 84:3823-3830(1999).
Li, HM; Lahti, JM; et al. Alternatively spliced cyclin C mRNA is widely expressed, cell cycle regulated, and encodes a truncated cyclin box. ONCOGENE 13:705-712(1996).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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