Anti-CDH18 monoclonal antibody (DMABT-H13383)
Mouse anti-Human CDH18 monoclonal antibody for WB, IHC, sELISA, ELISA
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CDH18 (NP_004925, 467 a.a. ~ 576 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
CDH18; cadherin 18, type 2; cadherin-18; CDH14; EY CADHERIN; cadherin-14
CDH18 (Cadherin 18) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19. This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. The function about CDH18 antigen include calcium ion binding.
Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem.
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Van Slambrouck, S; Grijelmo, C; et al. Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha 1-integrins during colon cancer cell invasion. INTERNATIONAL JOURNAL OF ONCOLOGY 31:1501-1508(2007).
Kawamoto, T; Shoda, J; et al. Expression of MUC1 recognized by a monoclonal antibody MY.1E12 is a useful biomarker for tumor aggressiveness of carcinoma of the gallbladder. CLINICAL & EXPERIMENTAL METASTASIS 21:353-362(2004).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.