Anti-CDH18 monoclonal antibody (DMABT-H13383)

Mouse anti-Human CDH18 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
7G8
Species Reactivity
Human
Immunogen
CDH18 (NP_004925, 467 a.a. ~ 576 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CDH18; cadherin 18, type 2; cadherin-18; CDH14; EY CADHERIN; cadherin-14
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CDH18 (Cadherin 18) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19. This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. The function about CDH18 antigen include calcium ion binding.
Pathway
Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem.

Citations


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References


Kawamoto, T; Shoda, J; et al. Expression of MUC1 recognized by a monoclonal antibody MY.1E12 is a useful biomarker for tumor aggressiveness of carcinoma of the gallbladder. CLINICAL & EXPERIMENTAL METASTASIS 21:353-362(2004).
Adachi, T; Takahashi, T; et al. Aggregation independent of N-cadherin and neural cell adhesion molecule on quail myoblasts transformed with temperature-sensitive Rous sarcoma virus. CELL ADHESION AND COMMUNICATION 6:39-50(1998).

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