Anti-CDH18 (aa 467-576) polyclonal antibody

Species Reactivity

Human

Immunogen

CDH18 (NP_004925, 467 a.a. ~ 576 a.a) partial recombinant protein with GST tag. The sequence is DLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFF LDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIP

Conjugate

Alternative Names

CDH18; cadherin 18, type 2; CDH14; CDH24; CDH14L; cadherin-18; cadherin-14; ey-cadherin; cadherin-like 24;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Pathway

Adherens junctions interactions; Cell-Cell communication;