Anti-CDH17 monoclonal antibody (DMABT-H13381)

Mouse anti-Human CDH17 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2I4
Species Reactivity
Human
Immunogen
CDH17 (NP_004054,35a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CDH17; cadherin 17, LI cadherin (liver-intestine); cadherin-17; cadherin; HPT 1; LI cadherin
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CDH17 (Cadherin 17) is a Protein Coding gene. Diseases associated with CDH17 include intrahepatic cholangiocarcinoma and epithelial predominant wilms tumor. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include calcium ion binding and proton-dependent oligopeptide secondary active transmembrane transporter activity. An important paralog of this gene is CDH16. This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.
Antigen Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. Cadherin-17 is a protein that in humans is encoded by the CDH17 gene. 0The function about CDH17 antigen include calcium ion binding; proton-dependent oligopeptide secondary active transmembrane transporter activity; transporter activity.

Citations


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References


Mokrowiecka, A; Zonnur, S; et al. Liver-Intestine-Cadherin Is a Sensitive Marker of Intestinal Differentiation During Barrett's Carcinogenesis. DIGESTIVE DISEASES AND SCIENCES 58:699-705(2013).
Wang, YG; Shek, FH; et al. Anti-Cadherin-17 Antibody Modulates Beta-Catenin Signaling and Tumorigenicity of Hepatocellular Carcinoma. PLOS ONE 8:-(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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