This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Function
protein binding; protein homodimerization activity;
Synonyms
CALCOCO2; calcium binding and coiled-coil domain 2; NDP52; calcium-binding and coiled-coil domain-containing protein 2; nuclear dot protein 52; nuclear domain 10 protein 52; nuclear domain 10 protein NDP52; antigen nuclear dot 52 kDa protein;
Citations
Publication ()
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