Anti-CALCOCO2 monoclonal antibody (DCABH-669)

Mouse anti-Human CALCOCO2 monoclonal antibody for WB, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
7F9
Species Reactivity
Human
Immunogen
Recombinant full length Human CALCOCO2 produced in HEK293T cells (NP_005822).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CALCOCO2; calcium binding and coiled-coil domain 2; calcium-binding and coiled-coil domain-containing protein 2; MGC17318; NDP52; nuclear dot protein 52
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CALCOCO2 (Calcium Binding And Coiled-Coil Domain 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is TAX1BP1. This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion. Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene. 0The function about CALCOCO2 antigen include protein binding; protein homodimerization activity.

Citations


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References


FAZIOLI, F; MINICHIELLO, L; et al. EPS15, A NOVEL TYROSINE KINASE SUBSTRATE, EXHIBITS TRANSFORMING ACTIVITY. MOLECULAR AND CELLULAR BIOLOGY 13:5814-5828(1993).
Abdel-Ghany, SE; Reddy, ASN; et al. A novel calcium/calmodulin-regulated kinesin-like protein is highly conserved between monocots and dicots. DNA AND CELL BIOLOGY 19:567-578(2000).

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