C1q Antigen

Product Overview

Purified from human plasma that has been tested and found to be negative for HIV, HCV and HBsAg antibodies. After coating onto ELISA plates the product will bind autoantibodies to prothrombin.

Target

C1q

Purity

The C1q antigen (A, B and C subunits; 29, 26 and 22 kDa respectively) is more than 95% pure, as assessed by SDS gel electrophoresis.

Concentration

0.5-2.0 mg/ml

Preservative

None

Storage

The product is stabilised with 20% glycerol and 0.1% Micr-O-protect TM. Store at -20°C or below (long term) or at +4°C (short term). Avoid repeated freezing and thawing. Mix thoroughly before use.

Introduction

The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin.
The sites are on the CH2 domain of IgG and, it is thought, on the CH4 domain of IgM.
The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity.

Keywords

C1q;C1Q complex;C1q Antigen;C1Q complex Antigen;