Human ACTL6A blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-BAF53A and BAF53B antibody

Target

BAF53A and BAF53B

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Function

contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding; contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding; chromatin binding; contributes_to nucleosomal DNA binding; protein binding; trans

Synonyms

ACTL6A; actin-like 6A; Arp4; ACTL6; BAF53A; INO80K; ARPN-BETA; actin-like protein 6A; BAF53; arpNbeta; hArpN beta; INO80 complex subunit K; actin-related protein 4; BAF complex 53 kDa subunit; BRG1-associated factor 53A; actin-related protein Baf53a; 53 kDa BRG1-associated factor A;