Anti-Influenza virus Nucleoprotein Monoclonal antibody (DMAB15660)

Mouse Anti-Influenza virus Nucleoprotein Monoclonal antibody for WB, IHC, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
JoB209
Species Reactivity
Influenza virus
Immunogen
Recombinant protein corresponding to influenza A virus nucleoprotein (H1N1).
Conjugate
Unconjugated

Target


Alternative Names
NP antibody; Nucleocapsid protein antibody; Nucleoprotein antibody; Protein N antibody; Mouse Anti-influena zvirus nucleoprotein Monoclonal Antibody; Anti-influena zvirus nucleoprotein Monoclonal Antibody

Product Background


Antigen Description
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein"s nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein"s nuclear localization signals, targeting the RNP to the nucleus.

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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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