mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.
Pathway
Hypusine synthesis from eIF5A-lysine; Metabolism of proteins; PTM: gamma carboxylation, hypusine formation and arylsulfatase activation; Post-translational protein modification;
Citations
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