Anti-eIF5A2 monoclonal antibody, clone FQS8523

Antibody Isotype

IgG

Clone

FQS8523

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide, corresponding to amino acid residues of Human eIF5A2.

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250; Flow Cyt: 1/10 - 1/100; ICC/IF: 1/100 - 1/250.

Alternative Names

EIF5A2; eukaryotic translation initiation factor 5A2; eukaryotic translation initiation factor 5A-2; eIF-5A-2; eukaryotic initiation factor 5A; EIF-5A2; eIF5AII;

Entrez Gene ID

UniProt ID

Antigen Description

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.

Pathway

Hypusine synthesis from eIF5A-lysine, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem.