General Notes
This product (Catalog No. DPABH-21521) is a rabbit-derived polyclonal antibody raised against human cbx7, targeting the amino acid region 12–75 of the protein. It has been affinity purified by Protein A. The CBX7 gene encodes chromobox protein 7, a key component of the Polycomb repressive complex 1 (PRC1), which maintains transcriptional repression of developmental and cell cycle regulatory genes through epigenetic modifications such as histone H3 lysine 27 trimethylation (H3K27me3) binding via its chromodomain. Located on chromosome 22q13.1 in humans, CBX7 consists of six exons and is ubiquitously expressed across tissues, with particularly high levels in the ovary and endometrium. The protein it produces, along with other PRC1 members like BMI1 and RING1, helps regulate cellular processes including senescence, proliferation, and differentiation by silencing target genes.
DPABH-21521 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-21521 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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