Anti-ZIC2 (aa 190-207) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Synthetic peptide: GRSEQYRQVASPRTDPYS conjugated to KLH, corresponding to amino acids 190-207 of Mouse Zic2.

Conjugate

Alternative Names

ZIC2; zinc finger protein of the cerebellum 2; zinc finger protein ZIC 2; kumba; GENA 29; odd-paired homolog; Zic family member 2 (odd-paired homolog, Drosophila); Ku; HPE5;

Entrez Gene ID

UniProt ID

Antigen Description

Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5-TGGGTGGTC-3. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.

Pathway

Hedgehog signaling pathway; PluriNetWork;