Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/1000 - 1/10000; Flow Cyt: 1/1000.
Target
Alternative Names
ZIC2; Zic family member 2; Zic family member 2 (odd paired Drosophila homolog) , Zic family member 2 (odd paired homolog, Drosophila); zinc finger protein ZIC 2; HPE5; Zinc finger protein of the cerebellum 2; Zic family member 2 (odd-paired homolog, Dros
Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5-TGGGTGGTC-3. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
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