Anti-ZEB1 monoclonal antibody, clone 4H7

Antibody Isotype

IgG2a

Clone

4H7

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to Human AREB6 aa 1-350 (N terminal). Produced in E.coli (NP_110378).Sequence: MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDA ADCEGVPEDDLPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQA DEAGCTVKDDECESDAENEQNHDPNVEEFLQQQDTAVIF

Conjugate

Application Notes

IHC-P: 1/150; WB: 1/2000.

Alternative Names

ZEB1; zinc finger E-box binding homeobox 1; posterior polymorphous corneal dystrophy 3 , PPCD3, TCF8, transcription factor 8 (represses interleukin 2 expression); zinc finger E-box-binding homeobox 1; AREB6; BZP; NIL 2 A; ZEB; Zfhep; Zfhx1a; negative reg

Entrez Gene ID

UniProt ID

Antigen Description

Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Pathway

Hypertrophy Model, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;