Anti-XBP1 monoclonal antibody, clone YCQ2I7F6

Antibody Isotype

IgG1

Clone

YCQ2I7F6

Species Reactivity

Human

Immunogen

Recombinant fragment (Human)

Conjugate

Alternative Names

XBP1; X-box binding protein 1; XBP2; X-box-binding protein 1; tax-responsive element-binding protein 5; TREB5; XBP-1;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5-GATGACGTG[TG]N(3)[AT]T-3, and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.

Pathway

Activation of Chaperone Genes by ATF6-alpha, organism-specific biosystem; Activation of Chaperone Genes by XBP1(S), organism-specific biosystem; Activation of Chaperones by ATF6-alpha, organism-specific biosystem; Activation of Chaperones by IRE1alpha, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem;